Research Publications

Sharing our work to promote advancements in the diagnosis of heart and lung diseases

Transthoracic Parametric Doppler for Bedside Diagnosis of Pulmonary Embolism: A Pilot Study

Journal of Clinical Ultrasound, December 2019

Authors: Marcia C, Javitt, Lydia Daniels, Maisa Andraous, Semyon Chulsky, Rachel Schatzberger, Nira Beck-Razi, Ludmilla Guralnik, Boris Oklander, Yoram Palti, Yishai Ofran, Diana Gaitini

Transthoracic parametric Doppler (TPD), unlike conventional ultrasonography, measures signals originating from movements of pulmonary blood vessel walls. In this pilot study, we tested TPD in 15 patients diagnosed with pulmonary embolism on computed tomography pulmonary angiography. Results were mapped to the upper, middle, and lower thirds of the right lung. In the lower third, TPD yielded 100% specificity and positive predictive value for acute pulmonary embolism. If validated in a larger series, this rapid bedside technique might obviate the need for computed tomography in specific cases. This could be advantageous in patients who are unstable,
in intensive care, or have allergies to iodinated contrast material.

Pulmonary Lung Doppler Signals: Normative Data in a Pediatric Population Compared with Adults

Journal of Clinical Monitoring and Computing 33(3) · January 2019

Authors: Burstein, Hopper, McCarthy, Hall, Schatzberger, Palti, Feinstein

 The aim of this study was to characterize LDS in healthy children to establish normative pediatric LDS data, and compare the pediatric data to the previously published healthy adult LDS. In this prospective, two-center study, LDS were acquired in children without cardiopulmonary disease using a 2 MHz transthoracic pulsed Doppler transducer. The data were processed to obtain Doppler velocity patterns corresponding to phases of the cardiac cycle. Signals were analyzed using a parametric Doppler signal-processing package and performance evaluation of the trained classifiers was performed using cross validation method. Pediatric signals were then compared to a retrospective cohort of healthy adults. 

Non-invasive Diagnosis of Pulmonary Hypertension from Lung Doppler Signal: A Proof of Concept Study

Journal of Clinical Monitoring and Computing, 2016

Authors: Godinas L. & al.

Transthoracic Parametric Doppler (TPD) is a novel ultrasound technique recently developed for the investigation of pulmonary blood vessels. Lung Doppler Signals (LDS) recorded from TPD provide information regarding the functional mechanical characteristics of pulmonary blood vessels. We aimed to define the specific profile of LDS generated from TPD imaging in patients with pulmonary hypertension (PH), and to evaluate the diagnostic performance of LDS to detect PH using right heart catheterization (RHC) as gold standard reference. 

Footprints of Cardiac Mechanical Activity as Expressed in Lung Doppler

Echocardiography: 2015: 32, pp: 407-410

Authors: Palti Y, Kanter A, Solter E, Schatzberger R, Kronzon I.

The aim of this research is to determine the diagnostic information contained in cardiac pulsatile pressure waves as expressed in the Doppler signals recorded over the right lung. The main conclusion is that the lung Doppler signals contain distinct signatures typical of arrhythmias such as AF and atrial flutter that can be used for both diagnosis and to gain insight into the nature of the phenomena.

Pulmonary Doppler Signals: a Potentially New Diagnostic Tool

European Journal of Echocardiography, 2011;12 (12) pp:940–944

Authors: Palti Y, Kanter A, Solter E, Schatzberger R, Kronzon.

 LDS originate from different elements and phases of cardiac activity that generate mechanical waves which propagate throughout the lung and are thus expressed in pulsatile changes in ultrasound reflections. While such signals could originate either from pulsatile blood flow or reflections from movement of the blood vessel–alveolar air interface, the experimental evidence points towards the tissue–air interface movements due to vessel expansion as the origin. The LDS can potentially be an important tool for diagnosing and characterizing cardio-pulmonary physiological states and diseases..

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